Superparamagnetic graphene quantum dot as a dual-modality contrast agent for confocal fluorescence microscopy and magnetomotive optical coherence tomography

被引：9
|
作者：
Li, Wei [1 ]
Song, Wenxing [2 ]
Chen, Biqiong [3 ]
Matcher, Stephen J. [1 ]
机构：
[1] Univ Sheffield, Dept Elect & Elect Engn, Broad Lane, Sheffield S3 7HQ, S Yorkshire, England
[2] Univ Sheffield, Dept Chem & Biol Engn, Sheffield, S Yorkshire, England
[3] Queens Univ Belfast, Sch Mech & Aerosp Engn, Belfast, Antrim, North Ireland
来源：
JOURNAL OF BIOPHOTONICS | 2019年 / 12卷 / 02期
基金：
英国工程与自然科学研究理事会;
关键词：
contrast agent; fluorescence microscopy; graphene; magnetomotive optical coherence tomography; quantum dot; IRON-OXIDE NANOPARTICLES; CELL-BASED THERAPY; DRUG-DELIVERY; STEM-CELLS; NANOCRYSTALS; DISEASE; BLUE; SIZE;
D O I：
10.1002/jbio.201800219
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A magnetic graphene quantum dot (MGQD) nanoparticle, synthesized by hydrothermally reducing and cutting graphene oxide-iron oxide sheet, was demonstrated to possess the capabilities of simultaneous confocal fluorescence and magnetomotive optical coherence tomography (MMOCT) imaging. This MGQD shows low toxicity, significant tunable blue fluorescence and superparamagnetism, which can thus be used as a dual-modality contrast agent for confocal fluorescence microscopy (CFM) and MMOCT. The feasibility of applying MGQD as a tracer of cells is shown by imaging and visualizing MGQD labeled cells using CFM and our in-house MMOCT. Since MMOCT and CFM can offer anatomical structure and intracellular details, respectively, the MGQD for cell tracking could provide a more comprehensive diagnosis.
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收藏
页数：11
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