Dual-modality fluorescence and full-field optical coherence microscopy for biomedical imaging applications

被引：32

作者：

Auksorius, Egidijus ^{[1
,2
]}

Bromberg, Yaron ^{[1
,2
]}

Motiejuenaite, Rueta ^{[3
,4
,5
]}

Pieretti, Alberto ^{[6
,7
]}

Liu, Linbo ^{[1
,2
]}

Coron, Emmanuel ^{[1
,2
]}

Aranda, Jorge ^{[3
,4
]}

Goldstein, Allan M. ^{[6
,7
]}

Bouma, Brett E. ^{[1
,2
,8
]}

Kazlauskas, Andrius ^{[3
,4
]}

Tearney, Guillermo J. ^{[1
,2
,8
,9
,10
]}

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Boston, MA 02114 USA

[4] Massachusetts Eye & Ear Infirm, Schepens Eye Res Inst, Boston, MA 02114 USA

[5] Vilnius Univ, Dept Biochem & Biophys, Vilnius, Lithuania

[6] Harvard Univ, Sch Med, Dept Pediat Surg, Boston, MA 02114 USA

[7] Massachusetts Gen Hosp, Boston, MA 02114 USA

[8] Harvard MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[9] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02114 USA

[10] Massachusetts Gen Hosp, Boston, MA 02114 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2012年 / 3卷 / 03期

关键词：

STRUCTURED ILLUMINATION; IN-VIVO; TOMOGRAPHY; LIGHT; ANGIOGENESIS; MOUSE; MODEL;

D O I：

10.1364/BOE.3.000661

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Full-field optical coherence microscopy (FFOCM) is a high-resolution interferometric technique that is particularly attractive for biomedical imaging. Here we show that combining it with structured illumination fluorescence microscopy on one platform can increase its versatility since it enables co-localized registration of optically sectioned reflectance and fluorescence images. To demonstrate the potential of this dual modality, a fixed and labeled mouse retina was imaged. Results showed that both techniques can provide complementary information and therefore the system could potentially be useful for biomedical imaging applications. (c) 2012 Optical Society of America

引用

页码：661 / 666

页数：6

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