The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases

被引：43

作者：

Rye, CS ^{[1
]}

Withers, SG ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

来源：

CARBOHYDRATE RESEARCH | 2004年 / 339卷 / 03期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

glycosaminoglycan; polysaccharide lyase; Flavobacterium heparinum; chondroitin; chondroitin AC;

D O I：

10.1016/j.carres.2003.12.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A thio-linked disaccharide based on the structure of the glycosaminoglycan chondroitin was synthesized as a potential inhibitor of chondroitin AC lyase from Flavobacterium heparinum for structural analysis of the active site. Instead it was found to be a slow substrate, thereby demonstrating that lyases, in contrast to glycosidases, can cleave thioglycoside links between sugars. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：699 / 703

页数：5

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