The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases

被引：43
|
作者：
Rye, CS [1 ]
Withers, SG [1 ]
机构：
[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada
来源：
CARBOHYDRATE RESEARCH | 2004年 / 339卷 / 03期
基金：
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词：
glycosaminoglycan; polysaccharide lyase; Flavobacterium heparinum; chondroitin; chondroitin AC;
D O I：
10.1016/j.carres.2003.12.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A thio-linked disaccharide based on the structure of the glycosaminoglycan chondroitin was synthesized as a potential inhibitor of chondroitin AC lyase from Flavobacterium heparinum for structural analysis of the active site. Instead it was found to be a slow substrate, thereby demonstrating that lyases, in contrast to glycosidases, can cleave thioglycoside links between sugars. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：699 / 703
页数：5
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