Solvent-Free Amination of Secondary Benzylic Alcohols with N-Nucleophiles Catalyzed by FeCl3

被引：11
|
作者：
Yu, Jian-Jun
Wang, Li-Min [1 ]
Guo, Feng-Lou
Liu, Jin-Qian
Liu, Ying
Jiao, Ning
机构：
[1] E China Univ Sci & Technol, Adv Mat Lab, Shanghai 200237, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 11期
关键词：
Amination; benzyl alcohols; benzyl amines; FeCl3; solvent free; PROPARGYLIC SUBSTITUTION-REACTION; BRONSTED ACID; ALLYLTRIMETHYLSILANE; CARBOXAMIDES; SULFONAMIDES; ALLYLATION; AMIDATION;
D O I：
10.1080/00397911.2010.488798
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[image omitted] A general, simple, and environmentally friendly method for the direct amination of secondary benzyl alcohols with amides or 4-nitroaniline is described. This method has been applied to a variety of substrates, and the reaction proceeded smoothly at room temperature under solvent-free conditions. CbzNH(2) was proved to be very useful in the direct preparation of the benzylic amines from corresponding alcohols.
引用
收藏
页码：1609 / 1616
页数：8
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