Design, synthesis, and biological evaluation of a novel class of fluorescein-based N-glycosylamines

被引：18
|
作者：
Rajasekar, Mani [1 ]
Khan, Sulaiman Mahaboob [2 ]
Devaraj, Sivasithamparam Niranjali [2 ]
Das, Thangamuthu Mohan [1 ]
机构：
[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India
[2] Univ Madras, Dept Biochem, Madras 600025, Tamil Nadu, India
来源：
CARBOHYDRATE RESEARCH | 2011年 / 346卷 / 13期
关键词：
Fluorescein derivatives; N-Glycosylamines; Organogelators; Morphological studies; Cell imaging studies; NITRIC-OXIDE DETECTION; COPPER-COMPLEXES; IN-VITRO; DERIVATIVES; PLATFORM; LIGANDS; CELL;
D O I：
10.1016/j.carres.2011.06.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of fluorescein-based N-glycosylamines was synthesized from the corresponding fluorescein amine and a partially protected D-glucose. The physiochemical investigation of these compounds by spectral and morphological studies reveals their gelation potential. The exclusive localization of fluorescence in the cytoplasm through cell imaging studies reveals the anti-cancer potentials of N-glycosylamines. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1776 / 1785
页数：10
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