Novel Fluorescein-Based Fluorescent Probe for Detecting H2S and Its Real Applications in Blood Plasma and Biological Imaging

被引：85
|
作者：
Jin, Xilang [1 ,2 ]
Wu, Shaoping [3 ]
She, Mengyao [1 ]
Jia, Yifan [1 ]
Hao, Likai [4 ]
Yin, Bing [1 ]
Wang, Lanying [1 ]
Obst, Martin [5 ]
Shen, Yehua [1 ]
Zhang, Yongmin [3 ]
Li, Jianli [1 ]
机构：
[1] Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710127, Shaanxi, Peoples R China
[2] Xian Technol Univ, Sch Mat & Chem Engn, Xian 710032, Shaanxi, Peoples R China
[3] Northwest Univ, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Biomed Key Lab Shaanxi Prov, Xian 710069, Shaanxi, Peoples R China
[4] Eberhard Karls Univ Tubingen, Inst Geosci, Ctr Appl Geosci, Holderlinstr 12, D-72074 Tubingen, Germany
[5] Univ Bayreuth, Bayreuth Ctr Ecol & Environm Res BayCEER, Dr Hans Frisch Str 1-3, D-95448 Bayreuth, Germany
来源：
ANALYTICAL CHEMISTRY | 2016年 / 88卷 / 22期
基金：
中国国家自然科学基金;
关键词：
HYDROGEN-SULFIDE; SELECTIVE DETECTION; RAPID DETECTION; VISUALIZATION; VASORELAXANT; DESIGN; RAT;
D O I：
10.1021/acs.analchem.6b04087
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A broad-spectrum fluorescent probe, which can be applied to monitoring H2S in various biological systems, has been rationally designed and synthesized. This specific probe was applied to localize the endogenous H2S in living Raw264.7 macrophage cells, HepG2 cells, and H9C2 cells. At the same time, the probe has successfully visualized CBS- and CSE-induced endogenous H2S production and monitored CBS and CSE activity in H9C2 cells. This probe could serve as a powerful molecular imaging tool to further explore the physiological function and the molecular mechanisms of endogenous H2S in living animal systems.
引用
收藏
页码：11253 / 11260
页数：8
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