New dibenzocyclooctadiene lignans from the Kadsura ananosma

被引：22

作者：

Yang, Jian-Hong ^{[1
,4
]}

Zhang, Hai-Yan ^{[2
]}

Du, Xue ^{[1
]}

Wang, Wei ^{[2
]}

Xiao, Wei-Lie ^{[1
]}

Wen, Jin ^{[3
]}

Pu, Jian-Xin ^{[1
]}

Tang, Xi-Can ^{[2
]}

Sun, Han-Dong ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China

[2] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[3] Yunnan Acad Forest Sci, Inst Trop Forestry, Kunming 650204, Peoples R China

[4] Acad Sci, Grad Univ Chinese, Beijing 100039, Peoples R China

来源：

TETRAHEDRON | 2011年 / 67卷 / 25期

关键词：

Kadsura ananosma; Dibenzocyclooctadiene lignans; Ananonins; Neuroprotective effect; C-19; HOMOLIGNANS; GOMISIN-G; HETEROCLITA; INTERIOR; CELLS; TRITERPENOIDS; PROTECTS; STEMS;

D O I：

10.1016/j.tet.2011.04.105

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fourteen new dibenzocyclooctadiene lignans, ananonins A-N (1-14), together with five known compounds, were isolated from the seeds of Kadsura ananosma. The structures and absolute configurations of 1-14 were established using a combination of MS, NMR, and CD techniques. The biological activity of these compounds was evaluated, and ananonin M (13) showed moderate neuroprotective effects in an in vitro assay. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：4498 / 4504

页数：7

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