New dibenzocyclooctadiene lignans from the Kadsura ananosma

被引：22
|
作者：
Yang, Jian-Hong [1 ,4 ]
Zhang, Hai-Yan [2 ]
Du, Xue [1 ]
Wang, Wei [2 ]
Xiao, Wei-Lie [1 ]
Wen, Jin [3 ]
Pu, Jian-Xin [1 ]
Tang, Xi-Can [2 ]
Sun, Han-Dong [1 ]
机构：
[1] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China
[2] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
[3] Yunnan Acad Forest Sci, Inst Trop Forestry, Kunming 650204, Peoples R China
[4] Acad Sci, Grad Univ Chinese, Beijing 100039, Peoples R China
来源：
TETRAHEDRON | 2011年 / 67卷 / 25期
关键词：
Kadsura ananosma; Dibenzocyclooctadiene lignans; Ananonins; Neuroprotective effect; C-19; HOMOLIGNANS; GOMISIN-G; HETEROCLITA; INTERIOR; CELLS; TRITERPENOIDS; PROTECTS; STEMS;
D O I：
10.1016/j.tet.2011.04.105
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Fourteen new dibenzocyclooctadiene lignans, ananonins A-N (1-14), together with five known compounds, were isolated from the seeds of Kadsura ananosma. The structures and absolute configurations of 1-14 were established using a combination of MS, NMR, and CD techniques. The biological activity of these compounds was evaluated, and ananonin M (13) showed moderate neuroprotective effects in an in vitro assay. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4498 / 4504
页数：7
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