Electrochemically Stimulated Release from Liposomes Embedded in a Polyelectrolyte Multilayer

被引：26

作者：

Graf, Norma ^{[1
,2
]}

Albertini, Francesco ^{[1
,2
]}

Petit, Tristan ^{[1
,2
]}

Reimhult, Erik ^{[3
]}

Voeroes, Janos ^{[1
,2
]}

Zambelli, Tomaso ^{[1
,2
]}

机构：

[1] Univ Zurich, Inst Biomed Engn, Lab Biosensors & Bioelect, CH-8092 Zurich, Switzerland

[2] ETH, CH-8092 Zurich, Switzerland

[3] Inst Nanobiotechnol NBT, A-1190 Vienna, Austria

来源：

ADVANCED FUNCTIONAL MATERIALS | 2011年 / 21卷 / 09期

关键词：

LAYER THIN-FILMS; PHOSPHOLIPID-VESICLES; EXPONENTIAL-GROWTH; DRUG-DELIVERY; CELL-ADHESION; ULTRASOUND; ARCHITECTURES; PRINCIPLES; STABILITY; DNA;

D O I：

10.1002/adfm.201002283

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Triggered release of an entrapped dye from vesicles embedded in a polyelectrolyte multilayer (PEM), as a consequence of the electrochemically induced local pH change in the vicinity of the electrode, is reported. The PEM was deposited on an indium tin oxide (ITO) electrode wherein lipid vesicles filled with a fluorescent dye were embedded. The use of vesicles with a strong negative charge and the polyelectrolyte species of the PEM matrix with a polycation as topmost layer enabled the generation of a stable layer of liposomes in the PEM.

引用

页码：1666 / 1672

页数：7

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