Epigenetic Regulatory Mechanisms Induced by Resveratrol

被引：103
|
作者：
Santos Fernandes, Guilherme Felipe [1 ,2 ]
Bernardes Silva, Gabriel Dalio [1 ]
Pavan, Aline Renata [1 ]
Chiba, Diego Eidy [1 ]
Chin, Chung Man [1 ]
Dos Santos, Jean Leandro [1 ]
机构：
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, Brazil
[2] Sao Paulo State Univ UNESP, Inst Chem, BR-14800060 Araraquara, Brazil
来源：
NUTRIENTS | 2017年 / 9卷 / 11期
基金：
巴西圣保罗研究基金会;
关键词：
resveratrol; epigenetic targets; histone deacetylase; SIRT1; DNA methyltransferase; histone acetyltransferase; NF-KAPPA-B; DOXORUBICIN-INDUCED CARDIOTOXICITY; HISTONE DEMETHYLASE LSD1; DNA METHYLATION PATTERNS; BREAST-CANCER CELLS; OXIDATIVE STRESS; LIFE-SPAN; SIRT1; ACTIVATION; MITOCHONDRIAL BIOGENESIS; PROTECTS CARDIOMYOCYTES;
D O I：
10.3390/nu9111201
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1).
引用
收藏
页数：27
相关论文
共 50 条
  • [41] Mechanisms governing epigenetic regulation of apoptosis in CTCL: Implications for therapy with methotrexate, JAK inhibitors, and resveratrol
    Nihal, M.
    Wood, G.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2020, 140 (07) : S32 - S32
  • [42] Epigenetic mechanisms underlying stress-induced depression
    de Carvalho, Luana Martins
    Chen, Wei-Yang
    Lasek, Amy W.
    EPIGENETICS, VOL 156, 2021, 156 : 87 - 126
  • [43] Molecular and epigenetic mechanisms of Cr(VI)-induced carcinogenesis
    Chen, Qiao Yi
    Murphy, Anthony
    Sun, Hong
    Costa, Max
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 377
  • [44] Epigenetic mechanisms of dietary restriction induced aging in Drosophila
    Lian, Ting
    Gaur, Uma
    Yang, Deying
    Li, Diyan
    Li, Ying
    Yang, Mingyao
    EXPERIMENTAL GERONTOLOGY, 2015, 72 : 38 - 44
  • [45] Role of epigenetic mechanisms in cisplatin-induced toxicity
    Franca Quintanilha, Julia Coelho
    Francinette Saavedra, Kathleen
    Visacri, Marilia Berlofa
    Moriel, Patricia
    Salazar, Luis A.
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2019, 137 : 131 - 142
  • [46] Epigenetic Mechanisms Underlying Anthracycline-Induced Cardiotoxicity
    Chen, Ching Kit
    Lim, Yee Phong
    Tan, Wilson Lek Wen
    Anene-Nzelu, George C.
    Ng Shi Ling
    Li Yiqing
    Danh, Tuan L.
    Foo, Roger Sik Yin
    CIRCULATION RESEARCH, 2019, 125
  • [47] Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency
    van den Hurk, Mark
    Kenis, Gunter
    Bardy, Cedric
    van den Hove, Daniel L.
    Gage, Fred H.
    Steinbusch, Harry W.
    Rutten, Bart P.
    EPIGENOMICS, 2016, 8 (08) : 1131 - 1149
  • [48] Epigenetic mechanisms underlying anthracycline-induced cardiotoxicity
    Chen, Ching Kit
    Lim, Yee Phong
    Anene-Nzelu, George C.
    Tan, Wilson L. W.
    Ng, Shi Ling
    Li, Yiqing
    Danh, Tuan L.
    Foo, Roger S. Y.
    PEDIATRIC TRANSPLANTATION, 2019, 23
  • [49] Epigenetic mechanisms shape the underlining expression regulatory mechanisms of the STAT3 in multiple sclerosis disease
    Hosseini, Arezoo
    Babaloo, Zohreh
    Gharibi, Tohid
    Shomali, Navid
    Marofi, Faroogh
    Hashemi, Vida
    Ayromlou, Hormoz
    Asadi, Milad
    Rahmani, Shima
    Noorolyai, Saeed
    Shanehbandi, Dariush
    Baradaran, Behzad
    BMC RESEARCH NOTES, 2020, 13 (01)
  • [50] Regulatory Mechanisms of Epigenetic miRNA Relationships in Human Cancer and Potential as Therapeutic Targets
    Arif, K. M. Taufiqul
    Elliott, Esther K.
    Haupt, Larisa M.
    Griffiths, Lyn R.
    CANCERS, 2020, 12 (10) : 1 - 26
12345