Epigenetic Regulatory Mechanisms Induced by Resveratrol

被引：103

作者：

Santos Fernandes, Guilherme Felipe ^{[1
,2
]}

Bernardes Silva, Gabriel Dalio ^{[1
]}

Pavan, Aline Renata ^{[1
]}

Chiba, Diego Eidy ^{[1
]}

Chin, Chung Man ^{[1
]}

Dos Santos, Jean Leandro ^{[1
]}

机构：

[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, Brazil

[2] Sao Paulo State Univ UNESP, Inst Chem, BR-14800060 Araraquara, Brazil

来源：

NUTRIENTS | 2017年 / 9卷 / 11期

基金：

巴西圣保罗研究基金会;

关键词：

resveratrol; epigenetic targets; histone deacetylase; SIRT1; DNA methyltransferase; histone acetyltransferase; NF-KAPPA-B; DOXORUBICIN-INDUCED CARDIOTOXICITY; HISTONE DEMETHYLASE LSD1; DNA METHYLATION PATTERNS; BREAST-CANCER CELLS; OXIDATIVE STRESS; LIFE-SPAN; SIRT1; ACTIVATION; MITOCHONDRIAL BIOGENESIS; PROTECTS CARDIOMYOCYTES;

D O I：

10.3390/nu9111201

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1).

引用

页数：27

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