Epigenetic Regulatory Mechanisms Induced by Resveratrol

被引：103
|
作者：
Santos Fernandes, Guilherme Felipe [1 ,2 ]
Bernardes Silva, Gabriel Dalio [1 ]
Pavan, Aline Renata [1 ]
Chiba, Diego Eidy [1 ]
Chin, Chung Man [1 ]
Dos Santos, Jean Leandro [1 ]
机构：
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, Brazil
[2] Sao Paulo State Univ UNESP, Inst Chem, BR-14800060 Araraquara, Brazil
来源：
NUTRIENTS | 2017年 / 9卷 / 11期
基金：
巴西圣保罗研究基金会;
关键词：
resveratrol; epigenetic targets; histone deacetylase; SIRT1; DNA methyltransferase; histone acetyltransferase; NF-KAPPA-B; DOXORUBICIN-INDUCED CARDIOTOXICITY; HISTONE DEMETHYLASE LSD1; DNA METHYLATION PATTERNS; BREAST-CANCER CELLS; OXIDATIVE STRESS; LIFE-SPAN; SIRT1; ACTIVATION; MITOCHONDRIAL BIOGENESIS; PROTECTS CARDIOMYOCYTES;
D O I：
10.3390/nu9111201
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1).
引用
收藏
页数：27
相关论文
共 50 条
  • [1] Epigenetic Regulatory Mechanisms in Stress-Induced Behavior
    Chakravarty, Sumana
    Pathak, Salil Saurav
    Maitra, Swati
    Khandelwal, Nitin
    Chandra, Karisetty Bhanu
    Kumar, Arvind
    EPIGENETICS, 2014, 115 : 117 - 154
  • [2] Epigenetic Regulatory Mechanisms Associated with Infertility
    Minocherhomji, Sheroy
    Madon, Prochi F.
    Parikh, Firuza R.
    OBSTETRICS AND GYNECOLOGY INTERNATIONAL, 2010, 2010
  • [3] Epigenetic regulatory mechanisms in cancer, development, and evolution
    Ruden, DM
    CURRENT GENOMICS, 2005, 6 (03) : 127 - 127
  • [4] Chromatin Insulators: Regulatory Mechanisms and Epigenetic Inheritance
    Bushey, Ashley M.
    Dorman, Elizabeth R.
    Corces, Victor G.
    MOLECULAR CELL, 2008, 32 (01) : 1 - 9
  • [5] Epigenetic Regulatory Mechanisms During Preimplantation Development
    Corry, Gareth N.
    Tanasijevic, Borko
    Barry, Evan R.
    Krueger, Winfried
    Rasmussen, Theodore P.
    BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS, 2009, 87 (04) : 297 - 313
  • [6] Integration of epigenetic regulatory mechanisms in heart failure
    Miron Sopic
    Emma L. Robinson
    Costanza Emanueli
    Prashant Srivastava
    Claudio Angione
    Carlo Gaetano
    Gianluigi Condorelli
    Fabio Martelli
    Thierry Pedrazzini
    Yvan Devaux
    Basic Research in Cardiology, 118
  • [7] Targeting epigenetic regulatory mechanisms in cancer chemoprevention
    Fay, JR
    Crowell, JA
    Kopelovich, L
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2005, 9 (02) : 315 - 328
  • [8] Integration of epigenetic regulatory mechanisms in heart failure
    Sopic, Miron
    Robinson, Emma L.
    Emanueli, Costanza
    Srivastava, Prashant
    Angione, Claudio
    Gaetano, Carlo
    Condorelli, Gianluigi
    Martelli, Fabio
    Pedrazzini, Thierry
    Devaux, Yvan
    BASIC RESEARCH IN CARDIOLOGY, 2023, 118 (01)
  • [9] Non-coding RNAs and their epigenetic regulatory mechanisms
    Zhou, Huihui
    Hu, Hu
    Lai, Maode
    BIOLOGY OF THE CELL, 2010, 102 (12) : 645 - 655
  • [10] Epigenetic regulatory mechanisms during preimplantation embryo development
    Palini, Simone
    De Stefani, Silvia
    Scala, Valentina
    Dusi, Ludovica
    Bulletti, Carlo
    REPRODUCTIVE SCIENCE, 2011, 1221 : 54 - 60
12345