Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers

被引：37

作者：

Milovan, Denise ^{[2
]}

Almeida, Luis ^{[1
,3
]}

Romach, Myroslava K. ^{[2
]}

Nunes, Teresa ^{[1
]}

Rocha, Jose Francisco ^{[1
]}

Sokowloska, Marta ^{[2
]}

Sellers, Edward M. ^{[2
]}

Soares-da-Silva, Patricio ^{[1
,4
]}

机构：

[1] BIAL Portela & Co SA, Dept Res & Dev, Sao Mamede Do Coronado, Portugal

[2] Kendle Early Stage, Toronto, ON, Canada

[3] Univ Aveiro, Hlth Sci Sect, P-3800 Aveiro, Portugal

[4] Univ Porto, Fac Med, Inst Pharmacol & Therapeut, P-4100 Oporto, Portugal

来源：

EPILEPSY & BEHAVIOR | 2010年 / 18卷 / 04期

关键词：

Antiepileptic drugs; Cognition; Eslicarbazepine acetate; Oxcarbazepine; Psychomotor performance; PARTIAL-ONSET SEIZURES; ADJUNCTIVE TREATMENT; ANTIEPILEPTIC DRUGS; CARBAMAZEPINE; PHARMACOKINETICS; EFFICACY; DERIVATIVES; BIA-2-093; DIAZEPAM; SAFETY;

D O I：

10.1016/j.yebeh.2010.04.022

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The results of two single-blind studies conducted to evaluate the cognitive and psychomotor effects of eslicarbazepine acetate and oxcarbazepine following single and repeated administration in healthy volunteers are reported. The cognitive and psychomotor evaluation consisted of several computerized and paper-and-pencil measures. Eslicarbazepine acetate and oxcarbazepine had similar overall cognitive profiles and did not cause clinically relevant cognitive impairment The incidence of adverse events was lower with eslicarbazepine acetate than with oxcarbazepine. (C) 2010 Published by Elsevier Inc.

引用

页码：366 / 373

页数：8

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