Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers

被引：37

作者：

Milovan, Denise ^{[2
]}

Almeida, Luis ^{[1
,3
]}

Romach, Myroslava K. ^{[2
]}

Nunes, Teresa ^{[1
]}

Rocha, Jose Francisco ^{[1
]}

Sokowloska, Marta ^{[2
]}

Sellers, Edward M. ^{[2
]}

Soares-da-Silva, Patricio ^{[1
,4
]}

机构：

[1] BIAL Portela & Co SA, Dept Res & Dev, Sao Mamede Do Coronado, Portugal

[2] Kendle Early Stage, Toronto, ON, Canada

[3] Univ Aveiro, Hlth Sci Sect, P-3800 Aveiro, Portugal

[4] Univ Porto, Fac Med, Inst Pharmacol & Therapeut, P-4100 Oporto, Portugal

来源：

EPILEPSY & BEHAVIOR | 2010年 / 18卷 / 04期

关键词：

Antiepileptic drugs; Cognition; Eslicarbazepine acetate; Oxcarbazepine; Psychomotor performance; PARTIAL-ONSET SEIZURES; ADJUNCTIVE TREATMENT; ANTIEPILEPTIC DRUGS; CARBAMAZEPINE; PHARMACOKINETICS; EFFICACY; DERIVATIVES; BIA-2-093; DIAZEPAM; SAFETY;

D O I：

10.1016/j.yebeh.2010.04.022

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The results of two single-blind studies conducted to evaluate the cognitive and psychomotor effects of eslicarbazepine acetate and oxcarbazepine following single and repeated administration in healthy volunteers are reported. The cognitive and psychomotor evaluation consisted of several computerized and paper-and-pencil measures. Eslicarbazepine acetate and oxcarbazepine had similar overall cognitive profiles and did not cause clinically relevant cognitive impairment The incidence of adverse events was lower with eslicarbazepine acetate than with oxcarbazepine. (C) 2010 Published by Elsevier Inc.

引用

页码：366 / 373

页数：8

共 50 条

[1] EFFECT OF ESLICARBAZEPINE ACETATE AND OXCARBAZEPINE ON COGNITION AND PSYCHOMOTOR FUNCTION IN HEALTHY VOLUNTEERS
Almeida, L.
Milovan, D.
Nunes, T.
Romach, M.
Rocha, J.
Sellers, E.
Sokowloska, M.
Soares-da-Silva, P.
EPILEPSIA, 2009, 50 : 113 - 113
[2] CSF and Plasma Pharmacokinetics of Eslicarbazepine Acetate and Oxcarbazepine in Healthy Volunteers
Kharidia, Jahnavi
Nunes, Teresa
Versavel, Mark
Zummo, Jacqueline
Blum, David
Maier, Gary
Soares-da-Silva, Patricio
NEUROLOGY, 2011, 76 (09) : A618 - A618
[3] Pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine at steady state in healthy volunteers
Elger, Christian
Bialer, Meir
Falcao, Amilcar
Vaz-da-Silva, Manuel
Nunes, Teresa
Almeida, Luis
Soares-da-Silva, Patricio
EPILEPSIA, 2013, 54 (08) : 1453 - 1461
[4] STEADY-STATE PHARMACOKINETICS AND TOLERABILITY OF ESLICARBAZEPINE ACETATE AND OXCARBAZEPINE IN HEALTHY VOLUNTEERS
Falcao, A.
Vaz-Da-Silva, M.
Nunes, T.
Almeida, L.
Soares-Da-Silva, P.
EPILEPSIA, 2012, 53 : 114 - 114
[5] The effect of olanzapine on cognition and psychomotor function in healthy elderly volunteers
Taylor, N
Beuzen, JN
Wesnes, K
Wood, A
SCHIZOPHRENIA RESEARCH, 1996, 18 (2-3) : VC2 - VC2
[6] STEADY-STATE PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS OF ESLICARBAZEPINE ACETATE AND OXCARBAZEPINE IN HEALTHY VOLUNTEERS
Nunes, T.
Rocha, J. F.
Falcao, A.
Almeida, L.
Soares-Da-Silva, P.
EPILEPSIA, 2012, 53 : 195 - 195
[7] EFFECTS OF ESLICARBAZEPINE ACETATE, ESLICARBAZEPINE, CARBAMAZEPINE AND OXCARBAZEPINE IN THE 6-HZ PSYCHOMOTOR SEIZURE MODEL IN THE MICE
Torrao, L.
Machado, R.
Pires, N.
Palma, N.
Bonifacio, M. J.
Wright, L. C.
Soares-da-Silva, P.
EPILEPSIA, 2011, 52 : 118 - 119
[8] Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers
Nunes, Teresa
Rocha, Jose Francisco
Falcao, Amilcar
Almeida, Luis
Soares-da-Silva, Patricio
EPILEPSIA, 2013, 54 (01) : 108 - 116
[9] MEMORY AND PSYCHOMOTOR EFFECTS OF OXCARBAZEPINE IN HEALTHY-HUMAN VOLUNTEERS
CURRAN, HV
JAVA, R
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1993, 44 (06) : 529 - 533
[10] Effects of oxcarbazepine and phenytoin on the EEG and cognition in healthy volunteers
Salinsky, MC
Spencer, DC
Oken, BS
Storzbach, D
EPILEPSY & BEHAVIOR, 2004, 5 (06) : 894 - 902

← 1 2 3 4 5 →