p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors

被引：43
|
作者：
Correa-Basurto, J
Alcántara, IV
Espinoza-Fonseca, LM
Trujillo-Ferrara, JG
机构：
[1] Escuela Super Med Inst Politecn Nacl, Secc Grad, Mexico City 11340, DF, Mexico
[2] Escuela Super Med Inst Politecn Nacl, Dept Bioquim, Mexico City 11340, DF, Mexico
[3] Comenius Univ, Fac Nat Sci, Dept Phys Chem, Bratislava 84215, Slovakia
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 40卷 / 07期
关键词：
acetylcholine; acetylcholinesterase; amides; imides; enzymatic inhibitors; molecular docking;
D O I：
10.1016/j.ejmech.2005.03.011
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Because Alzheimer's disease (AD) is a medical problem characterized by progressive loss of memory and cognition that is associated with a deficient cholinergic system, this work aims to evaluate some p-aminobenzoic acid (PABA) derivatives as acetylcholinesterase inhibitors in vitro, in continuation with our last studies. The assayed compounds are low toxic, simple-structured and low cost. (c) 2005 Elsevier SAS. All rights reserved.
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页码：732 / 735
页数：4
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