p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors

被引：43
|
作者：
Correa-Basurto, J
Alcántara, IV
Espinoza-Fonseca, LM
Trujillo-Ferrara, JG
机构：
[1] Escuela Super Med Inst Politecn Nacl, Secc Grad, Mexico City 11340, DF, Mexico
[2] Escuela Super Med Inst Politecn Nacl, Dept Bioquim, Mexico City 11340, DF, Mexico
[3] Comenius Univ, Fac Nat Sci, Dept Phys Chem, Bratislava 84215, Slovakia
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 40卷 / 07期
关键词：
acetylcholine; acetylcholinesterase; amides; imides; enzymatic inhibitors; molecular docking;
D O I：
10.1016/j.ejmech.2005.03.011
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Because Alzheimer's disease (AD) is a medical problem characterized by progressive loss of memory and cognition that is associated with a deficient cholinergic system, this work aims to evaluate some p-aminobenzoic acid (PABA) derivatives as acetylcholinesterase inhibitors in vitro, in continuation with our last studies. The assayed compounds are low toxic, simple-structured and low cost. (c) 2005 Elsevier SAS. All rights reserved.
引用
下载
收藏
页码：732 / 735
页数：4
相关论文
共 50 条
  • [21] Propanal hydroamination with p-aminobenzoic acid
    N. A. Magdalinova
    T. G. Volkova
    M. V. Klyuev
    M. S. Gruzdev
    Russian Journal of Organic Chemistry, 2010, 46 : 634 - 636
  • [22] Design and development of novel p-aminobenzoic acid derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer's disease
    Shrivastava, Sushant K.
    Sinha, Saurabh K.
    Srivastava, Pavan
    Tripathi, Prabhash N.
    Sharma, Piyoosh
    Tripathi, Manish K.
    Tripathi, Avanish
    Choubey, Priyanka K.
    Waiker, Digambar K.
    Aggarwal, Lalit M.
    Dixit, Manish
    Kheruka, Subhash C.
    Gambhir, Sanjay
    Shankar, Sharmila
    Srivastava, Rakesh K.
    BIOORGANIC CHEMISTRY, 2019, 82 : 211 - 223
  • [23] Simultaneous determination of p-aminobenzoic acid and its metabolites in the urine of volunteers, treated with p-aminobenzoic acid sunscreen formulation
    Wang, Lai-Hao
    Huang, Wen-Shiuan
    Tai, Huo-Mu
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2007, 43 (04) : 1430 - 1436
  • [24] ANALYSIS OF P-AMINOBENZOIC ACID-DERIVATIVES AND DEGRADATION PRODUCTS IN SUNSCREEN PREPARATIONS
    FITCH, PSH
    CROSBY, DG
    SHIBAMOTO, T
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1988, 196 : 219 - ANYL
  • [25] Metabolic kinetics of p-aminobenzoic acid in rabbits
    Song, DJ
    Ho, Y
    Hsu, KY
    BIOPHARMACEUTICS & DRUG DISPOSITION, 1999, 20 (05) : 263 - 270
  • [26] SPECTROPHOTOMETRIC MICRODETERMINATIONS OF ALDOSES WITH P-AMINOBENZOIC ACID
    BELL, DJ
    JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1966, (18): : 1638 - &
  • [27] π-Stacking effects on acid capacity of p-aminobenzoic acid
    Ebrahim Khalilinia
    Ali Ebrahimi
    Structural Chemistry, 2020, 31 : 1707 - 1716
  • [28] A microbiological assay method for p-aminobenzoic acid
    Thompson, RC
    Isbell, ER
    Mitchell, HK
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1943, 148 (02) : 281 - 287
  • [29] METABOLISM OF P-AMINOBENZOIC ACID BY RAT RETICULOCYTES
    CENEDELLA, RJ
    MARCUS, LK
    VANDYKE, K
    PHARMACOLOGIST, 1968, 10 (02): : 191 - +
  • [30] Twinned α p-Aminobenzoic Acid at 106 K
    Angela Hoffman
    Edward J. Valente
    Journal of Chemical Crystallography, 2019, 49 : 58 - 64
12345