p-Aminobenzoic acid derivatives as acetylcholinesterase inhibitors

被引：43

作者：

Correa-Basurto, J

Alcántara, IV

Espinoza-Fonseca, LM

Trujillo-Ferrara, JG

机构：

[1] Escuela Super Med Inst Politecn Nacl, Secc Grad, Mexico City 11340, DF, Mexico

[2] Escuela Super Med Inst Politecn Nacl, Dept Bioquim, Mexico City 11340, DF, Mexico

[3] Comenius Univ, Fac Nat Sci, Dept Phys Chem, Bratislava 84215, Slovakia

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2005年 / 40卷 / 07期

关键词：

acetylcholine; acetylcholinesterase; amides; imides; enzymatic inhibitors; molecular docking;

D O I：

10.1016/j.ejmech.2005.03.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Because Alzheimer's disease (AD) is a medical problem characterized by progressive loss of memory and cognition that is associated with a deficient cholinergic system, this work aims to evaluate some p-aminobenzoic acid (PABA) derivatives as acetylcholinesterase inhibitors in vitro, in continuation with our last studies. The assayed compounds are low toxic, simple-structured and low cost. (c) 2005 Elsevier SAS. All rights reserved.

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页码：732 / 735

页数：4

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