The in vivo metabolism of 5-(4-nitrophenyl)-4(2-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione in rats

被引：1
|
作者：
Oruç, EE
Kabasakal, L
Rollas, S
机构：
[1] Marmara Univ, Dept Pharmaceut Chem, Fac Pharm, TR-81010 Istanbul, Turkey
[2] Marmara Univ, Dept Pharmacol, Fac Pharm, TR-81010 Istanbul, Turkey
来源：
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS | 2003年 / 28卷 / 02期
关键词：
1,2,4-triazole-3-thione; in vivo metabolism; rat;
D O I：
10.1007/BF03190498
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The purpose of this study was to investigate the in vivo metabolism of 5-(4-nitrophenyl)-4-(2-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione. First its potential metabolites were synthesized and then the structures of the original compound were elucidated by UV, H-1-NMR and elemantary analysis. 40 mg dose was given intraperitoneally to rats. Blood samples were collected at 0, 0,5, 1, 2. 4. 6 12, 24, 48 and 72 hours after administration of substrate and blood was centrifuged to obtain plasma. The plasma were passed through a Sep-Pak C-18 cartridge. The samples were separated using HPLC on a reverse phase system. This study revealed reduction, N-acetylation and N-dealkylation as pathway of 5-(4-nitrophenyl)-4-(2-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione metabolism.
引用
收藏
页码：113 / 118
页数：6
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