The in vivo metabolism of 5-(4-nitrophenyl)-4(2-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione in rats

被引：1

作者：

Oruç, EE

Kabasakal, L

Rollas, S

机构：

[1] Marmara Univ, Dept Pharmaceut Chem, Fac Pharm, TR-81010 Istanbul, Turkey

[2] Marmara Univ, Dept Pharmacol, Fac Pharm, TR-81010 Istanbul, Turkey

来源：

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS | 2003年 / 28卷 / 02期

关键词：

1,2,4-triazole-3-thione; in vivo metabolism; rat;

D O I：

10.1007/BF03190498

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The purpose of this study was to investigate the in vivo metabolism of 5-(4-nitrophenyl)-4-(2-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione. First its potential metabolites were synthesized and then the structures of the original compound were elucidated by UV, H-1-NMR and elemantary analysis. 40 mg dose was given intraperitoneally to rats. Blood samples were collected at 0, 0,5, 1, 2. 4. 6 12, 24, 48 and 72 hours after administration of substrate and blood was centrifuged to obtain plasma. The plasma were passed through a Sep-Pak C-18 cartridge. The samples were separated using HPLC on a reverse phase system. This study revealed reduction, N-acetylation and N-dealkylation as pathway of 5-(4-nitrophenyl)-4-(2-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione metabolism.

引用

页码：113 / 118

页数：6

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