Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman-Birk soybean proteinase inhibitor

被引：5
|
作者：
Gladysheva, IP [1 ]
Polekhina, OV
Karmakova, TA
Nemtsova, ER
Yakubovskaya, RI
Shen, WC
Kennedy, AR
Larionova, NI
机构：
[1] Moscow MV Lomonosov State Univ, Moscow 119899, Russia
[2] Hertzen Moscow Oncol Inst, Moscow 125284, Russia
[3] Univ So Calif, Sch Pharm, Dept Pharmaceut Sci, Los Angeles, CA 90033 USA
[4] Univ Penn, Sch Med, Dept Radiat Oncol, Philadelphia, PA 19104 USA
来源：
JOURNAL OF CONTROLLED RELEASE | 2001年 / 74卷 / 1-3期
关键词：
soybean Bowman-Birk protease inhibitor (BBI) ethylene oxide and propylene oxide block copolymers; immunoconjugate; targeting; tumor;
D O I：
10.1016/S0168-3659(01)00337-6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The present work reports the effect of conjugation of the anticarcinogenic and antitumor soybean Bowman-Birk protease inhibitor (BBI) with amphiphilic block copolymer of ethylene oxide and propylene oxide (PEO-PPO) as well as with monoclonal antibody via clinical dextran (D) on tumor-targeted delivery of BBI. (C) 2001 Elsevier Science BY. All rights reserved.
引用
收藏
页码：303 / 308
页数：6
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