Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman-Birk soybean proteinase inhibitor

被引：5
|
作者：
Gladysheva, IP [1 ]
Polekhina, OV
Karmakova, TA
Nemtsova, ER
Yakubovskaya, RI
Shen, WC
Kennedy, AR
Larionova, NI
机构：
[1] Moscow MV Lomonosov State Univ, Moscow 119899, Russia
[2] Hertzen Moscow Oncol Inst, Moscow 125284, Russia
[3] Univ So Calif, Sch Pharm, Dept Pharmaceut Sci, Los Angeles, CA 90033 USA
[4] Univ Penn, Sch Med, Dept Radiat Oncol, Philadelphia, PA 19104 USA
来源：
JOURNAL OF CONTROLLED RELEASE | 2001年 / 74卷 / 1-3期
关键词：
soybean Bowman-Birk protease inhibitor (BBI) ethylene oxide and propylene oxide block copolymers; immunoconjugate; targeting; tumor;
D O I：
10.1016/S0168-3659(01)00337-6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The present work reports the effect of conjugation of the anticarcinogenic and antitumor soybean Bowman-Birk protease inhibitor (BBI) with amphiphilic block copolymer of ethylene oxide and propylene oxide (PEO-PPO) as well as with monoclonal antibody via clinical dextran (D) on tumor-targeted delivery of BBI. (C) 2001 Elsevier Science BY. All rights reserved.
引用
收藏
页码：303 / 308
页数：6
相关论文
共 42 条
  • [31] Proteolytic cleavage of soybean Bowman-Birk inhibitor monitored by means of high-performance capillary electrophoresis. Implications for the mechanism of proteinase inhibitors
    Jensen, B
    Unger, KK
    Uebe, J
    Gey, M
    Kim, YM
    Flecker, P
    JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 1996, 33 (03): : 171 - 185
  • [32] STUDIES ON THE SYNTHESIS OF PROTEINASE-INHIBITORS .2. SYNTHESIS OF CYCLIC NONAPEPTIDE FRAGMENTS AND ANALOGS RELATED TO THE REACTIVE SITES OF SOYBEAN BOWMAN-BIRK INHIBITOR
    TERADA, S
    SATO, K
    KATO, T
    IZUMIYA, N
    INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1980, 15 (05): : 441 - 454
  • [33] Gold Nanocluster-Conjugated Amphiphilic Block Copolymer for Tumor-Targeted Drug Delivery
    Chen, Tong
    Xu, Shuang
    Zhao, Tong
    Zhu, Ling
    Wei, Dongfeng
    Li, Yuanyuan
    Zhang, Haixia
    Zhao, Chunyan
    ACS APPLIED MATERIALS & INTERFACES, 2012, 4 (11) : 5766 - 5774
  • [34] Potential effects of plant protease inhibitors, oryzacystatin I and soybean Bowman-Birk inhibitor, on the aphid parasitoid Aphidius ervi Haliday (Hymenoptera, Braconidae)
    Azzouz, H
    Campan, EDM
    Cherqui, A
    Saguez, J
    Couty, A
    Jouanin, L
    Giordanengo, P
    Kaiser, L
    JOURNAL OF INSECT PHYSIOLOGY, 2005, 51 (08) : 941 - 951
  • [35] Oral administration of Bowman-Birk inhibitor concentrate, a soybean-derived protease inhibitor, suppresses EAE in the Lewis rat: A potential oral therapy for multiple sclerosis
    Rostami, A
    Gran, B
    Tabibzadeh, N
    Ventura, ES
    Ware, JH
    Kennedy, A
    NEUROLOGY, 2004, 62 (07) : A112 - A113
  • [36] Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery
    Prabaharan, Mani
    Grailer, Jamison J.
    Pilla, Srikanth
    Steeber, Douglas A.
    Gong, Shaoqin
    BIOMATERIALS, 2009, 30 (30) : 6065 - 6075
  • [37] Identification and pharmaceutical evaluation of novel frog skin-derived serine proteinase inhibitor peptide–PE-BBI (Pelophylax esculentus Bowman-Birk inhibitor) for the potential treatment of cancer
    Peng Lyu
    Lilin Ge
    Rui Ma
    Ran Wei
    Cian M. McCrudden
    Tianbao Chen
    Chris Shaw
    Hang Fai Kwok
    Scientific Reports, 8
  • [38] Identification and pharmaceutical evaluation of novel frog skin-derived serine proteinase inhibitor peptide PE-BBI (Pelophylax esculentus Bowman-Birk inhibitor) for the potential treatment of cancer
    Lyu, Peng
    Ge, Lilin
    Ma, Rui
    Wei, Ran
    McCrudden, Cian M.
    Chen, Tianbao
    Shaw, Chris
    Kwok, Hang Fai
    SCIENTIFIC REPORTS, 2018, 8
  • [39] Folate-conjugated multi-arm star amphiphilic block copolymer for tumor-targeted drug delivery
    Prabaharan, Mani
    Grailer, Jamison J.
    Pilla, Srikanth
    Steeber, Douglas A.
    Gong, Shaoqin
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238
  • [40] Amphiphilic multi-arm-block copolymer conjugated with doxorubicin via pH-sensitive hydrazone bond for tumor-targeted drug delivery
    Prabaharan, Mani
    Grailer, Jamison J.
    Pilla, Srikanth
    Steeber, Douglas A.
    Gong, Shaoqin
    BIOMATERIALS, 2009, 30 (29) : 5757 - 5766
12345