Haemolytic and proteinase activities in clinical isolates of Candida parapsilosis and Candida tropicalis with reference to the isolation anatomic site

被引：15
|
作者：
Franca, E. J. G. [1 ]
Furlaneto-Maia, L. [2 ]
Quesada, R. M. B. [3 ]
Favero, D. [1 ]
Oliveira, M. T. [1 ]
Furlaneto, M. C. [1 ]
机构：
[1] Univ Estadual Londrina, Dept Microbiol, Ctr Ciencias Biol, BR-86051990 Londrina, PR, Brazil
[2] Univ Tecnol Fed Parana, Londrina, PR, Brazil
[3] Univ Estadual Londrina, Ctr Ciencias Saude, BR-86051990 Londrina, PR, Brazil
来源：
MYCOSES | 2011年 / 54卷 / 04期
关键词：
Non-albicans Candida; haemolytic factor; proteinase; anatomic sites; HUMAN ORAL CANDIDOSIS; VIRULENCE FACTORS; ACID PROTEINASE; ALBICANS; PHOSPHOLIPASE; INFECTION; STRAINS; BLOOD; IDENTIFICATION; ONYCHOMYCOSIS;
D O I：
10.1111/j.1439-0507.2009.01825.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The aim of this study was to determine in vitro haemolytic and protease activities of Candida parapsilosis and Candida tropicalis isolates, obtained from anatomically distinct sites. Analysis of haemolytic activity of C. parapsilosis and C. tropicalis isolates obtained from the same anatomic site revealed that C. tropicalis isolates from blood had statistically higher activity (P < 0.05) than C. parapsilosis. On comparison of haemolytic activities of Candida isolates obtained from different anatomic sites, C. parapsilosis isolates from tracheal secretion were found to have higher activity than blood isolates. Protease activity was detected in the majority of the isolates analysed. Analysis of proteinase activity of C. parapsilosis and C. tropicalis isolates obtained from the same anatomic site revealed that C. parapsilosis isolates from tracheal secretion had statistically higher activity than C. tropicalis isolates. On comparison of proteinase activities of Candida isolates obtained from different anatomic sites, C. parapsilosis isolates from tracheal secretion were found to have higher activity than blood and superficial lesions isolates. Furthermore, C. tropicalis isolates from superficial lesions had higher activity than tracheal secretion isolates. Our results show the potential of C. parapsilosis and C. tropicalis isolates, obtained from distinct anatomic sites, to produce haemolytic factor and proteinases. Anatomic sites of isolation seem to be correlated with these activities, particularly for C. parapsilosis isolates.
引用
收藏
页码：E44 / E51
页数：8
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