Regulation of the cholinergic gene locus

被引：2

作者：

Tanaka, H ^{[1
]}

Shimojo, M ^{[1
]}

Wu, DH ^{[1
]}

Hersh, LB ^{[1
]}

机构：

[1] Univ Kentucky, Dept Biochem, Lexington, KY 40536 USA

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 02期

关键词：

choline acetyltransferase; vesicular acetylcholine transporter transcriptional regulation; coordinate regulation; protein kinase A;

D O I：

10.1016/S0928-4257(98)80154-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes. ((C) Elsevier, Paris).

引用

页码：149 / 152

页数：4

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