Regulation of the cholinergic gene locus

被引：2
|
作者：
Tanaka, H [1 ]
Shimojo, M [1 ]
Wu, DH [1 ]
Hersh, LB [1 ]
机构：
[1] Univ Kentucky, Dept Biochem, Lexington, KY 40536 USA
来源：
JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 02期
关键词：
choline acetyltransferase; vesicular acetylcholine transporter transcriptional regulation; coordinate regulation; protein kinase A;
D O I：
10.1016/S0928-4257(98)80154-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
DNase I hypersensitive site mapping of the human cholinergic gene locus has been used to detect cholinergic specific potential regulatory sites. Analysis of mutant PC12 cell lines provides evidence that protein kinase A II is required and coordinately regulates basal expression of both the ChAT and VAChT genes. ((C) Elsevier, Paris).
引用
收藏
页码：149 / 152
页数：4
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