Functional insights into pathogen biology from 3D electron microscopy

被引：10

作者：

Cyrklaff, Marek ^{[1
]}

Frischknecht, Friedrich ^{[1
]}

Kudryashev, Mikhail ^{[2
,3
]}

机构：

[1] Heidelberg Univ, Med Sch, Ctr Infect Dis, Integrat Parasitol, Neuenheimer Feld 324, D-69120 Heidelberg, Germany

[2] Max Planck Inst Biophys, Max von Laue Str 3, D-60438 Frankfurt, Germany

[3] Goethe Univ Frankfurt, Buchmann Inst Mol Life Sci, Max von Laue Str 17, D-60438 Frankfurt, Germany

来源：

FEMS MICROBIOLOGY REVIEWS | 2017年 / 41卷 / 06期

关键词：

cryo-electron tomography; HIV; Herpes Simplex Virus; Vaccinia virus; Plasmodium; bacterial pathogenesis; HERPES-SIMPLEX-VIRUS; CRYOELECTRON TOMOGRAPHY REVEALS; SIMIAN IMMUNODEFICIENCY VIRUS; III SECRETION SYSTEM; IN-SITU STRUCTURE; PLASMODIUM-FALCIPARUM; STRUCTURAL BIOLOGY; CELL-SHAPE; 3-DIMENSIONAL ARCHITECTURE; MACROMOLECULAR COMPLEXES;

D O I：

10.1093/femsre/fux041

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In recent years, novel imaging approaches revolutionised our understanding of the cellular and molecular biology of microorganisms. These include advances in fluorescent probes, dynamic live cell imaging, superresolution light and electron microscopy. Currently, a major transition in the experimental approach shifts electron microscopy studies from a complementary technique to a method of choice for structural and functional analysis. Here we review functional insights into the molecular architecture of viruses, bacteria and parasites as well as interactions with their respective host cells gained from studies using cryogenic electron tomography and related methodologies.

引用

页码：828 / 853

页数：26

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