Catching HIV 'in the act' with 3D electron microscopy

被引：19
|
作者：
Earl, Lesley A. [1 ]
Lifson, Jeffrey D. [2 ]
Subramaniam, Sriram [1 ]
机构：
[1] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA
[2] SAIC Frederick Inc, Frederick Natl Lab, AIDS & Canc Virus Program, Frederick, MD 21702 USA
来源：
TRENDS IN MICROBIOLOGY | 2013年 / 21卷 / 08期
基金：
美国国家卫生研究院;
关键词：
cryo-electron tomography; focused ion beam scanning electron microscopy (FIB-SEM); ion abrasion scanning electron microscopy (IA-SEM); vaccine design; virus-cell interaction; HUMAN-IMMUNODEFICIENCY-VIRUS; TO-CELL TRANSMISSION; HUMAN MONOCLONAL-ANTIBODIES; HIV-1/SIV CHIMERIC VIRUS; DENDRITIC CELLS; NEUTRALIZING ANTIBODIES; ENVELOPE GLYCOPROTEIN; POTENT NEUTRALIZATION; VIROLOGICAL SYNAPSE; TYPE-1; INFECTION;
D O I：
10.1016/j.tim.2013.06.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The development of a safe, effective vaccine to prevent HIV infection is a key step for controlling the disease on a global scale. However, many aspects of HIV biology make vaccine design problematic, including the sequence diversity and structural variability of the surface envelope glycoproteins and the poor accessibility of neutralization-sensitive epitopes on the virus. In this review, we discuss recent progress in understanding HIV in a structural context using emerging tools in 3D electron microscopy, and outline how some of these advances could be important for a better understanding of mechanisms of viral entry and for vaccine design.
引用
收藏
页码：397 / 404
页数：8
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