Catching HIV 'in the act' with 3D electron microscopy

被引：19

作者：

Earl, Lesley A. ^{[1
]}

Lifson, Jeffrey D. ^{[2
]}

Subramaniam, Sriram ^{[1
]}

机构：

[1] NCI, Cell Biol Lab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[2] SAIC Frederick Inc, Frederick Natl Lab, AIDS & Canc Virus Program, Frederick, MD 21702 USA

来源：

TRENDS IN MICROBIOLOGY | 2013年 / 21卷 / 08期

基金：

美国国家卫生研究院;

关键词：

cryo-electron tomography; focused ion beam scanning electron microscopy (FIB-SEM); ion abrasion scanning electron microscopy (IA-SEM); vaccine design; virus-cell interaction; HUMAN-IMMUNODEFICIENCY-VIRUS; TO-CELL TRANSMISSION; HUMAN MONOCLONAL-ANTIBODIES; HIV-1/SIV CHIMERIC VIRUS; DENDRITIC CELLS; NEUTRALIZING ANTIBODIES; ENVELOPE GLYCOPROTEIN; POTENT NEUTRALIZATION; VIROLOGICAL SYNAPSE; TYPE-1; INFECTION;

D O I：

10.1016/j.tim.2013.06.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of a safe, effective vaccine to prevent HIV infection is a key step for controlling the disease on a global scale. However, many aspects of HIV biology make vaccine design problematic, including the sequence diversity and structural variability of the surface envelope glycoproteins and the poor accessibility of neutralization-sensitive epitopes on the virus. In this review, we discuss recent progress in understanding HIV in a structural context using emerging tools in 3D electron microscopy, and outline how some of these advances could be important for a better understanding of mechanisms of viral entry and for vaccine design.

引用

页码：397 / 404

页数：8

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