Application of click-click chemistry to the synthesis of new multivalent RGD conjugates

被引：28
|
作者：
Galibert, Mathieu [1 ]
Sancey, Lucie [2 ]
Renaudet, Olivier [1 ]
Coll, Jean-Luc [2 ]
Dumy, Pascal [1 ]
Boturyn, Didier [1 ]
机构：
[1] UMR CNRS UJF 5250, Dept Chim Mol, ICMG FR 2607, F-38041 Grenoble 9, France
[2] INSERM, U823, Inst Albert Bonniot, F-38042 Grenoble 9, France
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 22期
关键词：
ONE-POT; CELL-ADHESION; SOLID-PHASE; PEPTIDES; AFFINITY; OXIME; CYCLOADDITIONS; INHIBITION; DENDRIMERS; LIGATION;
D O I：
10.1039/c0ob00070a
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New multivalent RGD-containing macromolecules were designed by exploiting two orthogonal chemoselective ligations. They were next applied to a competitive cell adhesion assay and used for the non invasive optical imaging of tumour in small animals.
引用
收藏
页码：5133 / 5138
页数：6
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