An efficient one-pot synthesis of tri-substituted thiophenes via a multicomponent reaction in water

被引：11

作者：

Moghaddam, Firouz Matloubi ^{[1
]}

Bardajee, Ghasem Rezanejade ^{[2
]}

Dolabi, Maliheh ^{[1
]}

机构：

[1] Sharif Univ Technol, Dept Chem, Lab Organ Synth & Nat Prod, Tehran, Iran

[2] Payame Noor Univ, Dept Chem, Qazvin Branch, Qazvin, Iran

来源：

JOURNAL OF SULFUR CHEMISTRY | 2010年 / 31卷 / 05期

关键词：

amides; cyclization; multicomponent reaction; nitriles; thiophene; DERIVATIVES;

D O I：

10.1080/17415993.2010.496129

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient one-pot synthesis of functionalized trisubstituted thiophenes via the reaction of 3-morpholino-3-thioxopropanenitrile, cyclohexyl isocyanide and -haloketones is reported. This method provides a straightforward route to a variety of highly substituted thiophenes not easily accessible by conventional methods.

引用

页码：387 / 393

页数：7

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