X-Ray Computed Tomography Imaging of Breast Cancer by using Targeted Peptide-Labeled Bismuth Sulfide Nanoparticles

被引：191

作者：

Kinsella, Joseph M. ^{[1
]}

Jimenez, Rebecca E.

Karmali, Priya P. ^{[2
,3
]}

Rush, Anthony M. ^{[1
]}

Kotamraju, V. Ramana ^{[2
,3
]}

Gianneschi, Nathan C. ^{[1
]}

Ruoslahti, Erkki ^{[2
,3
]}

Stupack, Dwayne

Sailor, Michael J. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Univ Calif Santa Barbara, Ctr Nanomed, Sanford Burnham Med Res Inst, Santa Barbara, CA 93106 USA

[3] Canc Ctr Sanford Burnham Med Res Inst, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 51期

基金：

美国国家卫生研究院;

关键词：

cancer; imaging agents; nanomedicine; nanoparticles; peptides; GOLD NANOPARTICLES; CONTRAST AGENT; HOMING PEPTIDE; QUANTUM DOTS; CELLS;

D O I：

10.1002/anie.201104507

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enhanced visualization of breast cancer in X-ray computed tomography was achieved by using Bi 2S 3 nanoparticles of 10 nm diameter modified to display a tumor targeting peptide (LyP-1, CGNKRTRGC). Accumulation within the tumor was increased by 260-% over non-labeled nanoparticles. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：12308 / 12311

页数：4

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