Comparison of enzymatic and GC-MS/MS analysis of creatinine in urine samples

被引：0
|
作者：
Ferenczy, Viktoria [1 ,2 ]
Kotora, Peter [1 ]
Hudecova, Dusana [1 ]
Blasko, Jaroslav [1 ]
Kubinec, Robert [1 ]
Behulova, Darina [2 ]
机构：
[1] Comenius Univ, Fac Nat Sci, Inst Chem, Ilkovicova 6, Bratislava 84215, Slovakia
[2] Univ Childrens Hosp, Dept Lab Med, Ctr Inherited Metab Dis, Bratislava 83340, Slovakia
来源：
PROCEEDINGS OF THE 11TH INTERNATIONAL STUDENTS CONFERENCE "MODERN ANALYTICAL CHEMISTRY" | 2015年
关键词：
creatinine; enzymatic analysis; GC-MS/MS; silylation; urine; MASS-SPECTROMETRY; METABOLITES;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Work was focused on the comparison of enzymatic and gas chromatographic tandem mass spectrometric analysis of creatinine and the simultaneous analysis of creatinine and fructose with GC-MS/MS after silylation with hexa methyldisilazaneand N,O-bis(trimethylsilyl) trifluoroacetamide. This method allows the direct derivatization of urine samples without sample pretreatment before derivatization. Because of this, the analysis and the diagnostics of diseases are faster than in case of a separate determination of both analytes.
引用
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页码：7 / 11
页数：5
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