Comparison of enzymatic and GC-MS/MS analysis of creatinine in urine samples

被引：0

作者：

Ferenczy, Viktoria ^{[1
,2
]}

Kotora, Peter ^{[1
]}

Hudecova, Dusana ^{[1
]}

Blasko, Jaroslav ^{[1
]}

Kubinec, Robert ^{[1
]}

Behulova, Darina ^{[2
]}

机构：

[1] Comenius Univ, Fac Nat Sci, Inst Chem, Ilkovicova 6, Bratislava 84215, Slovakia

[2] Univ Childrens Hosp, Dept Lab Med, Ctr Inherited Metab Dis, Bratislava 83340, Slovakia

来源：

PROCEEDINGS OF THE 11TH INTERNATIONAL STUDENTS CONFERENCE "MODERN ANALYTICAL CHEMISTRY" | 2015年

关键词：

creatinine; enzymatic analysis; GC-MS/MS; silylation; urine; MASS-SPECTROMETRY; METABOLITES;

D O I：

暂无

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Work was focused on the comparison of enzymatic and gas chromatographic tandem mass spectrometric analysis of creatinine and the simultaneous analysis of creatinine and fructose with GC-MS/MS after silylation with hexa methyldisilazaneand N,O-bis(trimethylsilyl) trifluoroacetamide. This method allows the direct derivatization of urine samples without sample pretreatment before derivatization. Because of this, the analysis and the diagnostics of diseases are faster than in case of a separate determination of both analytes.

引用

页码：7 / 11

页数：5

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