SYNTHESIS AND BIOLOGICAL ACTIVITY OF O-ISOBORNYLPHENOL DERIVATIVES

被引：20

作者：

Plotnikov, M. B. ^{[1
]}

Smol'yakova, V. I. ^{[1
]}

Ivanov, I. S. ^{[1
]}

Kuchin, A. V. ^{[2
]}

Chukicheva, I. J. ^{[2
]}

Buravlev, E. V. ^{[2
]}

Krasnov, E. A. ^{[3
]}

机构：

[1] Russian Acad Med Sci, Tomsk Sci Ctr, State Inst Pharmacol, Siberian Branch, Tomsk, Russia

[2] Russian Acad Sci, Inst Chem, Ural Branch, Komi Sci Ctr, Syktyvkar, Russia

[3] Siberian State Med Univ, Tomsk, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2011年 / 44卷 / 10期

关键词：

o-isobornylphenol; derivatives; synthesis; hemorheological properties; antiaggregant properties; PLATELET-AGGREGATION; FREE-RADICALS; VITAMIN-E; ACID;

D O I：

10.1007/s11094-011-0511-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hemorheological and antiaggregant properties of new o-isobornylphenol derivatives were investigated in ex vivo experiments. 4-Methyl-2,6-diisobornylphenol and 2-(dibutylamino)methyl-4-methyl-6-isobornylphenol hydrochloride demonstrated the maximum hemorheological activity. After intragastric administration, these compounds decreased the blood viscosity at low shear rates, suppressed the development of blood "hyperviscosity" before incubation (20.0 +/- 0.4 degrees C, 1 h), and reduced ADP-induced (4 x 10(-6) M) aggregation of platelets. The hemorheological and antiaggregant effects of the investigated compounds were comparable to those of pentoxifylline.

引用

页码：530 / 533

页数：4

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