Synthesis and antioxidant properties of benzimidazole derivatives with isobornylphenol fragments

被引：0
|
作者：
I. A. Dvornikova
E. V. Buravlev
I. V. Fedorova
O. G. Shevchenko
I. Yu. Chukicheva
A. V. Kutchin
机构：
[1] Institute of Chemistry of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences,
[2] Institute of Biology of the Komi Science Centre of the Ural Branch of the Russian Academy of Sciences,undefined
来源：
Russian Chemical Bulletin | 2019年 / 68卷
关键词：
1; -benzimidazoles; sterically hindered phenols; isobornylphenols; antioxidant activity; membrane-protective activity; red blood cells; oxidative hemolysis;
D O I：
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学科分类号：
摘要：
A series of new 2-substituted-1H-benzimidazoles was synthesized on the basis of 4-hydroxybenzaldehydes. Their antioxidant properties were evaluated in the in vitro models and compared with those of known analogs. The structural specifi c features of the molecules responsible for the high antioxidant activity were revealed. Among tested derivatives, 2-substituted 1H-benzimidazole containing a phenol fragment with isobornyl and tert-butyl groups was found to have the greatest ability to protect biomolecules and cells under conditions of acute oxidative stress.
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页码：1000 / 1005
页数：5
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