Synthesis and antioxidant properties of N-substituted aminomethyl derivatives of 2-isobornylphenol

被引：0
|
作者：
E. V. Buravlev
O. G. Shevchenko
机构：
[1] Ural Branch of the Russian Academy of Sciences,Institute of Chemistry, Komi Scientific Centre
[2] Ural Branch of the Russian Academy of Sciences,Institute of Biology, Komi Scientific Centre
来源：
Russian Chemical Bulletin | 2020年 / 69卷
关键词：
aminomethylation; Mannich bases; antioxidant activity; membrane-protective activity; erythrocytes; oxidative hemolysis; aminomethyl derivatives of 2-isobornylphenol;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of 2-isobornylphenol derivatives containing aminomethyl groups either at ortho-(monoderivatives) or ortho- and para-positions (bis-derivatives) relative to the hydroxy group of phenol moiety was synthesized. Antioxidant properties of the obtained compounds were comparatively evaluated using in vitro models. It was demonstrated that Mannich bases containing an n-octylaminomethyl group are significantly exceeding both starting 2-isobornylphenol and the standard antioxidant, 2,6-di-tert-butyl-4-methylphenol, by their ability to inhibit H2O2-induced erythrocyte hemolysis.
引用
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页码：1971 / 1978
页数：7
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