Structure-hemolytic activity relationship in isobornylphenol derivatives

被引：15
|
作者：
Shevchenko, O. G. [1 ]
Plyusnina, S. N. [1 ]
Buravlev, E. V. [2 ]
Chukicheva, I. Yu. [2 ]
Fedorova, I. V. [2 ]
Shchukina, O. V. [2 ]
Kutchin, A. V. [2 ]
机构：
[1] Russian Acad Sci, Ural Branch, Komi Sci Ctr, Inst Biol, 28 Ul Kommunist Skaya, Syktyvkar 167982, Russia
[2] Russian Acad Sci, Ural Branch, Komi Sci Ctr, Inst Chem, 48 Ul Pervomaiskaya, Syktyvkar 167000, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2017年 / 66卷 / 10期
关键词：
terpenylphenols; isobornylphenols; aminomethylphenols; alkoxymethylphenols; antioxidants; erythrocyte; biomembrane; hemolysis; morphological transformation of erythrocytes; scanning electron microscopy; MEMBRANE-PROTECTIVE ACTIVITY; AFFECTED IN-VITRO; HUMAN ERYTHROCYTES; MOLECULAR-MODELS; BUTYLATED HYDROXYTOLUENE; ANTIOXIDANT ACTIVITY; ALPHA-MANGOSTIN; POSITION; 2,6-DIISOBORNYL-4-METHYLPHENOL; 2,6-DIISOBORNYLPHENOL;
D O I：
10.1007/s11172-017-1962-x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A structure-hemolytic activity relationship in isobornylphenol derivatives was analysed. The morphological transformation of erythrocytes under the influence of some representatives of this class of compounds was demonstrated by scanning electron microscopy. The hemolytic activity of the test compounds can vary within wide limits, depending on the structure and position of substituents determining the nature of the interaction of the compound with the cell membrane.
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页码：1881 / 1890
页数：10
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