Regulation of fetal male germ cell development by members of the TGFβ superfamily

被引：18
|
作者：
Spiller, Cassy [1 ]
Burnet, Guillaume [1 ]
Bowles, Josephine [1 ,2 ]
机构：
[1] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia
来源：
STEM CELL RESEARCH | 2017年 / 24卷
基金：
英国医学研究理事会;
关键词：
Germ cells; TGF beta; Activins; Nodal; Cripto; EMBRYONIC STEM-CELLS; RETINOIC ACID; ACTIVIN-A; SUPPRESSES MEIOSIS; TESTIS DEVELOPMENT; MOUSE TESTIS; MICE; CRIPTO; SEX; DIFFERENTIATION;
D O I：
10.1016/j.scr.2017.07.016
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
There is now substantial evidence that members of the transforming growth factor-beta (TGF beta family) regulate germ cell development in the mouse fetal testis. Correct development of germ cells during fetal life is critical for establishment of effective spermatogenesis and for avoiding the formation of testicular germ cell cancer in later life. Here we consider the evidence for involvement of various TGF beta family members, attempt to reconcile discrepancies and clarify what we believe to be the likely in vivo roles of these factors. Crown Copyright (C) 2017 Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license.
引用
收藏
页码：174 / 180
页数：7
相关论文
共 50 条
  • [21] Dynamic regulation of mitotic arrest in fetal male germ cells
    Western, Patrick S.
    Miles, Denise C.
    van den Bergen, Jocelyn A.
    Burton, Matt
    Sinclair, Andrew H.
    STEM CELLS, 2008, 26 (02) : 339 - 347
  • [22] Involvement of members of the TGF-β superfamily in vascular smooth muscle cell biology
    King, KE
    Weissberg, PL
    Shanahan, CM
    BONE, 1999, 24 (04) : 410 - 410
  • [23] The roles of the TGF-β superfamily members in oocyte and somatic cell interactions.
    Drummond, A
    Dyson, M
    Farnworth, P
    Ooi, G
    Stanton, P
    Findlay, J
    BIOLOGY OF REPRODUCTION, 2004, : 89 - 89
  • [24] Members of the ErbB receptor tyrosine kinases are involved in germ cell development in fetal mouse gonads
    Toyoda-Ohno, H
    Obinata, M
    Matsui, Y
    DEVELOPMENTAL BIOLOGY, 1999, 215 (02) : 399 - 406
  • [25] Male germ cell apoptosis: regulation and biology
    Shaha, Chandrima
    Tripathi, Rakshamani
    Mishra, Durga Prasad
    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2010, 365 (1546) : 1501 - 1515
  • [26] Male Germ Cell Development in Humans
    Stukenborg, Jan-Bernd
    Kjartansdottir, Kristin Ros
    Reda, Ahmed
    Colon, Eugenia
    Albersmeier, Jan Philipp
    Soder, Olle
    HORMONE RESEARCH IN PAEDIATRICS, 2014, 81 (01): : 2 - 12
  • [27] Synergistic signaling of CNTF and TGF-β superfamily members
    Pitts, RL
    Conover, J
    Coulombe, JN
    Symes, AJ
    FASEB JOURNAL, 1999, 13 (04): : A194 - A194
  • [28] Epigenetic regulation of fetal germ cell differentiation.
    Resnick, JL
    Maatouk, DM
    Kellam, LD
    Mann, M
    Bartolomei, MS
    Li, E
    BIOLOGY OF REPRODUCTION, 2005, : 164 - 164
  • [29] TGF-β superfamily signaling in testis formation and early male germline development
    Young, Julia C.
    Wakitani, Shoichi
    Loveland, Kate L.
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2015, 45 : 94 - 103
  • [30] Alternative neural crest cell fates are instructively promoted by TGF beta superfamily members
    Shah, NM
    Groves, AK
    Anderson, DJ
    CELL, 1996, 85 (03) : 331 - 343
12345