Roles of microRNAs during glioma tumorigenesis and progression

被引：32
|
作者：
Wang, Shuwei [1 ]
Yin, Yutong [2 ]
Liu, Shuang [1 ]
机构：
[1] PLA, Navy Gen Hosp, Dept Neurosurg, Beijing 100048, Peoples R China
[2] Beijing 8 High Sch, Beijing, Peoples R China
来源：
HISTOLOGY AND HISTOPATHOLOGY | 2019年 / 34卷 / 03期
关键词：
Development; Glioma; Occurrence; miRNA; Diagnosis; Therapy; CELL-PROLIFERATION; INHIBITS PROLIFERATION; MALIGNANT PHENOTYPE; INDUCED APOPTOSIS; U87MG CELLS; GLIOBLASTOMA; INVASION; TEMOZOLOMIDE; EXPRESSION; GROWTH;
D O I：
10.14670/HH-18-040
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Glioma is the most common and aggressive type of brain tumor. It has a poor prognosis and a high recurrence rate. Despite continued advances in surgery, chemotherapy and radiotherapy, the clinical outcomes remain dismal. MicroRNAs (miRNAs) play important roles in the initiation and progression of a multitude of tumors. Until now, the molecular mechanism that is responsible for glioma tumorigenesis and progression remains unclear. Increasing evidence has shown that miRNAs play an important role in glioma. In this review, we focus on the current advances in determining the role of miRNAs in regulating tumorigenesis and the progression of glioma. In addition, the relevant roles of miRNAs about the diagnosis and target therapy have been clarified.
引用
收藏
页码：213 / 222
页数：10
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