Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression

被引：8
|
作者：
Wei, Zeyu [1 ,2 ,3 ,4 ]
Shi, Yijia [1 ,2 ,3 ,4 ]
Xue, Changning [1 ,2 ,4 ,5 ]
Li, Mengna [1 ,2 ,4 ,5 ]
Wei, Jianxia [1 ,2 ,4 ,5 ]
Li, Guiyuan [1 ,2 ,4 ,5 ]
Xiong, Wei [1 ,2 ,4 ,5 ]
Zhou, Ming [1 ,2 ,4 ,5 ]
机构：
[1] Cent South Univ, Hunan Canc Hosp, NHC Key Lab Carcinogenesis, Changsha 410013, Hunan, Peoples R China
[2] Cent South Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha 410013, Hunan, Peoples R China
[3] Cent South Univ, Xiangya Stomatol Hosp, Changsha 410078, Hunan, Peoples R China
[4] Cent South Univ, Canc Res Inst, Changsha 410078, Hunan, Peoples R China
[5] Cent South Univ, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Educ, Changsha 410078, Hunan, Peoples R China
来源：
JOURNAL OF CANCER | 2022年 / 13卷 / 15期
基金：
中国国家自然科学基金;
关键词：
circHIPK3; dual roles; differential expression; regulation mechanism; tumorigenesis; REGULATES CELL-PROLIFERATION; PROSTATE-CANCER CELLS; GASTRIC-CANCER; COLORECTAL-CANCER; MOLECULAR PATHOGENESIS; PANCREATIC-CANCER; CERVICAL-CANCER; OVARIAN-CANCER; PROMOTES; MIGRATION;
D O I：
10.7150/jca.78090
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CircHIPK3 is a type of endogenous circular RNA, which contains a covalently closed circular structure and cannot encode protein or polypeptide. CircHIPK3 is unusually expressed in varieties of tumors and plays dual roles of tumor promotion or tumor inhibition in tumorigenesis and development of tumors by serving as the sponge for miRNA in multiple tumors. Here, we reviewed the differential expression, the dual functions, the regulation mechanism, and the network in a variety of tumors as well as the potential value for the diagnosis and treatment of tumors, which are of great significance for our comprehensive understanding of the roles and mechanisms of circHIPK3 in tumors.
引用
收藏
页码：3674 / 3686
页数：13
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