Small open reading frames in 5′ untranslated regions of mRNAs

被引：19
|
作者：
Yamashita, R
Suzuki, Y
Nakai, K
Sugano, S
机构：
[1] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Genome Struct Anal,Minato Ku, Tokyo 1088639, Japan
[2] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Genome Database,Minato Ku, Tokyo 1088639, Japan
[3] Nara Inst Sci & Technol, Taisho Lab Funct Genomics, Nara, Japan
来源：
COMPTES RENDUS BIOLOGIES | 2003年 / 326卷 / 10-11期
关键词：
cap; open reading frame; untranslated region; transcriptional start site; house keeping genes; full-length cDNA;
D O I：
10.1016/j.crvi.2003.09.028
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Using the 5'-end sequence data from 'oligo-capped' cDNAs, we generated a representative full-length cDNA dataset for 4870 RefSeq entries, and analyzed the 5' untranslated region (UTR) of these genes. To our surprise, about half of the 4870 genes had an upstream ATG before the ATG that starts the longest open reading frame (ORF), suggesting that about half of them have small ORFs in their 5' UTR of average length of 31 amino acids. They require attention for further analysis to identify their biological role. (C) 2003 Academie des sciences. Published by Elsevier SAS. All rights reserved.
引用
收藏
页码：987 / 991
页数：5
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