Three-component reaction of 2-alkynylbenzaldehyde, amine, and nucleophile using Lewis acid-surfactant combined catalyst in water

被引:74
|
作者
Ye, Yang [1 ]
Ding, Qiuping [1 ,3 ]
Wu, He [1 ,2 ]
机构
[1] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[3] Jiangxi Normal Univ, Analyt Ctr Phys & Chem, Nanchang 330027, Peoples R China
基金
中国国家自然科学基金;
关键词
Lewis acid-surfactant combined catalyst; water; ultrasonic; 1,2-dihydroisoquinoline;
D O I
10.1016/j.tet.2007.11.055
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Lewis acid-surfactant combined catalyst (LASC) catalyzed three-component reactions of 2-alkynylbenzaldehyde, amines, and nucleophiles (alkyne, nitromethane, or diethyl phosphate) in water under ultrasonic conditions afforded the corresponding 1,2-dihydroisoquinoline derivatives in good yields. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1378 / 1382
页数:5
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