Caspase-8: Clipping off RIG-I Signaling

被引：3

作者：

Roth, Susanne ^{[1
]}

Ruland, Juergen ^{[1
,2
]}

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Inst Mol Immunol, D-81675 Munich, Germany

[2] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Lab Signaling Immune Syst, D-85764 Neuherberg, Germany

来源：

IMMUNITY | 2011年 / 34卷 / 03期

关键词：

RECOGNITION; ACTIVATION; RECEPTORS; NEMO;

D O I：

10.1016/j.immuni.2011.03.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmodulating the response are ill defined. In this issue of Immunity, Rajput et al. (2011) describe caspase-8-mediated RIP1 cleavage as a key step for restricting RIG-I signaling.

引用

页码：283 / 285

页数：3

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