Caspase-8: Clipping off RIG-I Signaling

被引：3
|
作者：
Roth, Susanne [1 ]
Ruland, Juergen [1 ,2 ]
机构：
[1] Tech Univ Munich, Klinikum Rechts Isar, Inst Mol Immunol, D-81675 Munich, Germany
[2] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Lab Signaling Immune Syst, D-85764 Neuherberg, Germany
来源：
IMMUNITY | 2011年 / 34卷 / 03期
关键词：
RECOGNITION; ACTIVATION; RECEPTORS; NEMO;
D O I：
10.1016/j.immuni.2011.03.011
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmodulating the response are ill defined. In this issue of Immunity, Rajput et al. (2011) describe caspase-8-mediated RIP1 cleavage as a key step for restricting RIG-I signaling.
引用
收藏
页码：283 / 285
页数：3
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