Cooccurring JAK2 V617F and R1063H mutations increase JAK2 signaling and neutrophilia in myeloproliferative neoplasms

被引：6

作者：

Mambet, Cristina ^{[1
,2
,3
]}

Babosova, Olga ^{[4
]}

Defour, Jean-Philippe ^{[2
,5
]}

Leroy, Emilie ^{[1
,2
]}

Necula, Laura ^{[3
]}

Stanca, Oana ^{[6
,7
]}

Tatic, Aurelia ^{[7
,8
]}

Berbec, Nicoleta ^{[6
,7
]}

Coriu, Daniel ^{[7
,8
]}

Belickova, Monika ^{[9
]}

Kralova, Barbora ^{[10
]}

Lanikova, Lucie ^{[4
]}

Vesela, Jitka ^{[9
]}

Pecquet, Christian ^{[1
,2
]}

Saussoy, Pascale ^{[5
]}

Havelange, Violaine ^{[11
]}

Diaconu, Carmen C. ^{[3
]}

Divoky, Vladimir ^{[10
]}

Constantinescu, Stefan N. ^{[1
,2
,3
]}

机构：

[1] Ludwig Inst Canc Res, Brussels Branch, Brussels, Belgium

[2] Catholic Univ Louvain, de Duve Inst, Brussels, Belgium

[3] Stefan S Nicolau Inst Virol, Mol Profiling Myeloproliferat Neoplasms & Acute L, Bucharest, Romania

[4] Acad Sci Czech Republ, Inst Mol Genet, Dept Cell & Dev Biol, Prague, Czech Republic

[5] Catholic Univ Louvain, Clin Univ St Luc, Dept Biol Clin, Brussels, Belgium

[6] Coltea Clin Hosp, Dept Hematol, Bucharest, Romania

[7] Carol Davila Univ Med & Pharm, Dept Radiol Oncol & Hematol, Bucharest, Romania

[8] Fundeni Clin Inst, Ctr Hematol & Bone Marrow Transplantat, Bucharest, Romania

[9] Inst Hematol & Blood Transfus, Prague, Czech Republic

[10] Palacky Univ, Fac Med & Dent, Dept Biol, Hnevotinska 3, CZ-77515 Olomouc, Czech Republic

[11] Clin Univ St Luc, Serv Hematol, Brussels, Belgium

来源：

BLOOD | 2018年 / 132卷 / 25期

关键词：

ESSENTIAL THROMBOCYTHEMIA; POLYCYTHEMIA-VERA;

D O I：

10.1182/blood-2018-04-843060

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

[No abstract available]

引用

页码：2695 / 2699

页数：7

共 50 条

[21] JAK-STAT PATHWAY IN MYELOPROLIFERATIVE NEOPLASMS: FROM JAK2 V617F TO CALRETICULIN MUTANTS
Constantinescu, S. N.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2017, 121 : 31 - 31
[22] JAK2 R1063H Variant Enhances V617F Constitutive Signaling and Favors Development of Essential Thrombocythemia with Increased Hemoglobin and Neutrophils
Mambet, Cristina
Defour, Jean-Philippe
Babosova, Olga
Leroy, Emilie
Necula, Laura
Stanca, Oana
Tatic, Aurelia
Coriu, Daniel
Belickova, Monika
Kralova, Barbora
Lanikova, Lucie
Saussoy, Pascale
Havelange, Violaine
Diaconu, Carmen C.
Divoky, Vladimir
Constantinescu, Stefan N.
BLOOD, 2018, 132
[23] No evidence for amplification of V617F JAK2 in myeloproliferative disorders
A V Jones
D J Bunyan
N C P Cross
Leukemia, 2007, 21 : 2561 - 2563
[24] JAK2 V617F: implications for thrombosis in myeloproliferative diseases
Hexner, Elizabeth O.
CURRENT OPINION IN HEMATOLOGY, 2007, 14 (05) : 450 - 454
[25] FREQUENCY OF JAK2 EXON 12 MUTATIONS IN JAK2 (V617F) NEGATIVE PATIENTS WITH CHRONIC MYELOPROLIFERATIVE DISORDERS (CMD)
Bernardi, M.
Ruggeri, M.
Albiero, E.
Madeo, D.
Rodeghiero, F.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 294 - 294
[26] Angiogenesis in JAK2 V617F positive myeloproliferative neoplasms and ruxolitinib decrease VEGF, HIF-1 enesis in JAK2 V617F positive cells
Cheng, Zhiyong
Fu, Jianzhu
Liu, Guimin
Zhang, Lijun
Xu, Qian
Wang, Su-yun
LEUKEMIA & LYMPHOMA, 2018, 59 (01) : 196 - 203
[27] THE JAK2 RS10974944 SNP, PART OF JAK2 46/1 HAPLOTYPE, STRONGLY PREDISPOSES TO JAK2 V617F POSITIVE MYELOPROLIFERATIVE NEOPLASMS
Trifa, A.
Cucuianu, A.
Petrov, L.
Urian, L.
Dima, D.
Militaru, M.
Pop, I.
Popp, R.
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2010, 95 : 598 - 598
[28] JAK2 V617F mutation detection in chronic myeloproliferative neoplasms by digital PCR
Waterhouse, M.
Pfeifer, D.
Follo, M.
Bertz, H.
Finke, J.
ONCOLOGY RESEARCH AND TREATMENT, 2017, 40 : 196 - 196
[29] Association of TNF polymorphisms with JAK2 (V617F) myeloproliferative neoplasms in Brazilian patients
Macedo, Luciana Conci
Quintero, Fernanda de Cesare
Pagliari-E-Silva, Sara
Barbosa Pagnano, Katia Borgia
Rodrigues, Camila
de Alencar, Josiane Bazzo
Sell, Ana Maria
Laguila Visentainer, Jeane Eliete
BLOOD CELLS MOLECULES AND DISEASES, 2016, 57 : 54 - 57
[30] A molecular diagnostic algorithm for JAK2 V617F investigations in suspected myeloproliferative neoplasms
Mark Alexander Catherwood
Roisin McAllister
Patrick McCallion
Julie Elizabeth McGimpsey
Andrew Hindley
John Feerick
Greame Greenfield
Paul Kennedy
Gary Benson
Claire Arnold
Bridgin Merron
Mary Frances McMullin
Irish Journal of Medical Science (1971 -), 2020, 189 : 621 - 626

← 1 2 3 4 5 →