Regulatory B cell phenotype and mechanism of action: the impact of stimulating conditions

被引：18
|
作者：
Wasik, Magdalena [1 ]
Nazimek, Katarzyna [1 ]
Bryniarski, Krzysztof [1 ]
机构：
[1] Jagiellonian Univ, Dept Immunol, Coll Med, 18 Czysta St, PL-31121 Krakow, Poland
来源：
MICROBIOLOGY AND IMMUNOLOGY | 2018年 / 62卷 / 08期
关键词：
autoimmune diseases; Breg cell; immunoregulation; infectious diseases; SYSTEMIC-LUPUS-ERYTHEMATOSUS; T-CELLS; B10; CELLS; STAPHYLOCOCCUS-AUREUS; IL-10; PRODUCTION; GRANZYME-B; AUTOIMMUNE INFLAMMATION; ADENOSINE PRODUCTION; IMMUNE SUPPRESSION; VIRUS INFECTION;
D O I：
10.1111/1348-0421.12636
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A diverse population of regulatory B (Breg) cells reportedly exhibits significant immunomodulatory effects in various models of inflammatory responses and infectious diseases caused by bacteria, viruses or parasites. Breg cells contribute to maintenance of homeostasis via IL-10 production and multiple IL-10-independent mechanisms. The current review describes various phenotypic and functional subsets of Breg cells in autoimmune and infectious diseases and discusses the impacts of experimental conditions that have been found to drive Breg cell differentiation.
引用
收藏
页码：485 / 496
页数：12
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