Regulatory B cell phenotype and mechanism of action: the impact of stimulating conditions

被引：18
|
作者：
Wasik, Magdalena [1 ]
Nazimek, Katarzyna [1 ]
Bryniarski, Krzysztof [1 ]
机构：
[1] Jagiellonian Univ, Dept Immunol, Coll Med, 18 Czysta St, PL-31121 Krakow, Poland
来源：
MICROBIOLOGY AND IMMUNOLOGY | 2018年 / 62卷 / 08期
关键词：
autoimmune diseases; Breg cell; immunoregulation; infectious diseases; SYSTEMIC-LUPUS-ERYTHEMATOSUS; T-CELLS; B10; CELLS; STAPHYLOCOCCUS-AUREUS; IL-10; PRODUCTION; GRANZYME-B; AUTOIMMUNE INFLAMMATION; ADENOSINE PRODUCTION; IMMUNE SUPPRESSION; VIRUS INFECTION;
D O I：
10.1111/1348-0421.12636
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A diverse population of regulatory B (Breg) cells reportedly exhibits significant immunomodulatory effects in various models of inflammatory responses and infectious diseases caused by bacteria, viruses or parasites. Breg cells contribute to maintenance of homeostasis via IL-10 production and multiple IL-10-independent mechanisms. The current review describes various phenotypic and functional subsets of Breg cells in autoimmune and infectious diseases and discusses the impacts of experimental conditions that have been found to drive Breg cell differentiation.
引用
收藏
页码：485 / 496
页数：12
相关论文
共 50 条
  • [21] MECHANISM OF ACTION OF THE IF-1 REGULATORY LOCUS
    DAIGNEAULT, L
    COULOMBE, B
    SKUP, D
    JOURNAL OF INTERFERON RESEARCH, 1987, 7 (06): : 716 - 716
  • [22] Impact of Uremia on Regulatory T Lymphocytes Proliferation and Phenotype
    Valentini, Nicolas
    Raymond, Maxime
    Lamarche, Caroline
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2022, 33 (11): : 879 - 879
  • [23] VIH-1 induce a deregulation in B-cell populations through a regulatory B-cell-like phenotype in vitro
    Lopez-Abente, J.
    Munoz-Fernandez, M. A.
    Correa-Rocha, R.
    Pion, M.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 628 - 628
  • [24] Regulatory B cells: Phenotype, function and role in transplantation
    Wortel, C. M.
    Heidt, S.
    TRANSPLANT IMMUNOLOGY, 2017, 41 : 1 - 9
  • [25] Azatryosine - Mechanism of action for conversion of transformed phenotype to normal
    Monden, Y
    Hamano-Takaku, F
    Shindo-Okada, N
    Nishimura, S
    ANTICANCER MOLECULES: STRUCTURE, FUNCTION, AND DESIGN, 1999, 886 : 109 - 121
  • [26] MECHANISM OF STIMULATING EFFECT PRODUCED BY POLYANIONS ON SYNTHESIS OF PROTEINS IN ISOLATED CELL NUCLEI FOLLOWING ACTION OF DEOXYRIBONUCLEASE
    SALGANIK, RI
    MOROZOVA, TM
    DREVICH, VF
    GRYAZNOVA, IM
    DOKLADY AKADEMII NAUK SSSR, 1962, 145 (02): : 453 - &
  • [27] IL-10-independent regulatory B-cell subsets and mechanisms of action
    Ray, Avijit
    Wang, Luman
    Dittel, Bonnie N.
    INTERNATIONAL IMMUNOLOGY, 2015, 27 (10) : 531 - 536
  • [28] Coupling the transcriptional regulatory action to Brn-3b to the cell cycle clock
    Zhu, T
    Sukumar, S
    CANCER BIOLOGY & THERAPY, 2004, 3 (03) : 324 - 325
  • [29] Investigating the impact of regulatory B cells and regulatory B cell-related genes on bladder cancer progression and immunotherapeutic sensitivity
    Zhou, Jiawei
    Zhou, Ranran
    Zhu, Yuanchao
    Deng, Shikai
    Muhuitijiang, Bahaerguli
    Li, Chengyao
    Shi, Xiaojun
    Zhang, Ling
    Tan, Wanlong
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2024, 43 (01)
  • [30] The technical impact of the unbundling process and regulatory action
    Ödling, P
    Mayr, B
    Palm, S
    IEEE COMMUNICATIONS MAGAZINE, 2000, 38 (05) : 74 - 80
12345