Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana

被引：1
|
作者：
Suksamrarn, S
Suwannapoch, N
Phakhodee, W
Thanuhiranlert, J
Ratananukul, P
Chimnoi, N
Suksamrarn, A
机构：
[1] Srinakharinwirot Univ, Fac Sci, Dept Chem, Bangkok 10110, Thailand
[2] Chulabhorn Res Inst, Bangkok 10210, Thailand
[3] Ramkhamhang Univ, Fac Sci, Dept Chem, Bangkok 10240, Thailand
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2003年 / 51卷 / 07期
关键词：
antituberculosis; prenylated xanthone; Garcinia mangostana; Mycobacterium tuberculosis; structure-activity relationship;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. alpha- and beta-Mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 mug/ml. Tri- and tetra-oxygenated xanthones with di-C-5 units or with a C-5 and a modified C-5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.
引用
收藏
页码：857 / 859
页数：3
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