Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata

被引：9

作者：

Zhang, Bao-Jun ^{[1
,2
,3
]}

Fu, Wen-Wei ^{[1
,2
]}

Wu, Rong ^{[1
,2
]}

Yang, Jin-Ling ^{[1
,2
]}

Yao, Cai-Yun ^{[4
]}

Yan, Bing-Xiong ^{[4
]}

Tan, Hong-Sheng ^{[1
,2
]}

Zheng, Chang-Wu ^{[1
,2
]}

Song, Zhi-Jun ^{[4
]}

Xu, Hong-Xi ^{[1
,2
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Sch Pharm, Cai Lun Lu 1200, Shanghai 201203, Peoples R China

[2] Engn Res Ctr Shanghai Coll TCM New Drug Discovery, Shanghai, Peoples R China

[3] ShangHai PuTuo Dist People Hosp, Dept Pharm, Shanghai, Peoples R China

[4] Guangxi Bot Garden Med Plants, Chang Gang Lu 189, Nanning 530023, Peoples R China

来源：

PLANTA MEDICA | 2019年 / 85卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Garcinia bracteata; Clusiaceae; prenylated xanthones; cytotoxicity; BIOASSAY-GUIDED ISOLATION; BIPHENYL DERIVATIVES; BARK; BENZOYLPHLOROGLUCINOLS; IDENTIFICATION; ROOTS; TWIGS;

D O I：

10.1055/a-0828-9831

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Six new prenylated xanthones (1-6) and seventeen known xanthones were isolated from extracts of Garcinia bracteata leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The inhibitory activities of the isolates were assayed on HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines. Compounds 1 and 15-17 showed moderate inhibitory effects on tumor cell growth, with IC(50)s ranging from 3.7 to 14.7 mu M.

引用

页码：444 / 452

页数：9

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