Distribution of M1 and M2 macrophages in cerebral granulomas caused by Encephalitozoon cuniculi

被引：1

作者：

Soto-Dominguez, Adolfo ^{[1
]}

Gonzalez-Castillo, Jennifer A. ^{[2
]}

Castillo-Velazquez, Uziel ^{[2
]}

Rodriguez-Tovar, Luis E. ^{[2
]}

Mendez-Zamora, Gerardo ^{[3
]}

Zamora-Avila, Diana E. ^{[4
]}

Nevarez-Garza, Alicia M. ^{[2
]}

机构：

[1] Cuerpo Acad Consolidado Morfol & Histol, Aguascalientes, Aguascalientes, Mexico

[2] Cuerpo Acad Consolidado Zoonosis & Enfermedades E, Aguascalientes, Aguascalientes, Mexico

[3] Cuerpo Acad Consolidado Prod Agr Biotecnol & Prod, Aguascalientes, Aguascalientes, Mexico

[4] Cuerpo Acad Consolidado Epidemiol Vet, Aguascalientes, Aguascalientes, Mexico

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2022年 / 252卷

关键词：

Arg-1; Encephalitozoon cuniculi; Granuloma; iNOS; M1; macrophage; M2; POLARIZATION;

D O I：

10.1016/j.vetimm.2022.110481

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Encephalitozoon cuniculi spores cause severe granulomatous inflammation in the brain where mononuclear cells and macrophages infiltrate. Here, we orally infected New Zealand white rabbits with 1 x 106 E. cuniculi viable spores to study the recruitment and localization of macrophages in brain granulomas. At day 30 post-infection, the positive phenotype markers iNOS (M1) and Arg-1 (M2) were located in the periphery and center of gran-ulomas, respectively. Live intracytoplasmic spores were found only in positive Arg-1 cells. This is the first work to describe the recruitment and distribution of M1 and M2 macrophages in the brain granulomas of rabbits infected with E. cuniculi.

引用

页数：4

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